Figures 440 (upper) and 441 (lower) from Chapter 16 (Cytoplasmic matrix and cytoskeleton) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Examples of the dense cytoskeletal network in the periphery of cells in vitro. In the upper panel, two microtubules traverse the meshwork of actin filaments. This cell was prepared by treated with Triton to extract soluble proteinaceous material, washed, quick frozen with liquid helium, deep etched, and rotary shadowed. Image by John Heuser. A PDF copy of the accompanying chapter is available on the ASCB’s BioEDUCATE website.