Molecules designed to block the expanded CAG repeats characteristic of Huntington's disease fluoresce blue in these cultured cells and prevent the expression of the mutant proteins that cause the disease.
See: J. Hu et al.(2009) Allele-specific silencing of mutant huntintin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol 27:478-484.
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