Smooth, Canoe-Shaped Keratocytes Migrate "Coherently", with Fast Speeds and Persistent Shapes, whereas Rough, D-Shaped Keratocytes Migrate "Decoherently", with Slower Speeds and Fluctuating Shapes Smooth, coherent keratocytes (top), which have EGFP-VASP enriched as a thin line at the leading edge, maintain their shape and migrate faster than rough, decoherent cells (bottom). The coherent keratocyte shown migrates at approximately twice the speed of the decoherent one. The leading edge and overall shape of the decoherent cell changes rapidly and widely compared to the coherent one. Scale bar 20 micron. Corresponds to video S1 in PLos Biology 5:2035-2052, 2007.