Shown are a normal human fibroblasts stained for lamin A (red), a major component of the nuclear lamina. Other images in this group show the envelope abnormalities that occur in HGPS patients carryin...

Wild type Trypanosoma brucei cells (Strain 427) were high pressure frozen and visualized through transmission electron microscopy (TEM). The images show the nucleus of the cells and the black arrow ...

Wild type Trypanosoma brucei cells (Strain 427) were high pressure frozen and visualized through transmission electron microscopy (TEM). The images show the nucleus of the cells and the black arrow ...

Wild type Trypanosoma brucei cells (Strain 427) were high pressure frozen and visualized through transmission electron microscopy (TEM). The images show the nucleus of the cells and the black arrow ...

Wild type Schizosaccharomyces pombe cells (cdc25-22) were high pressure frozen and visualized through transmission electron microscopy (TEM). The images show the nucleus of the cells and the black a...

Wild type Schizosaccharomyces pombe cells (cdc25-22) were high pressure frozen and visualized through transmission electron microscopy (TEM). The images show the nucleus of the cells and the black a...

High resolution view of the nuclear envelope of both the macronucleus, seen here, and the micronucleus consists of 2 membranes containing numerous perforations called pores. Proteins are imported thro...

The nuclear envelope of both the macronucleus, seen here, and the micronucleus consists of 2 membranes containing numerous perforations called pores. Proteins are imported through these pores and ribo...

Shown are fibroblasts from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (red), a major component of the nuclear lamina. The morphology of the envelop...

High resolution transmission electron micrograph of Halteria showing both the large macronucleus with nuclear pores, dense heterochromatin bodies and nucleolus, and the small micronucleus.