Transmission electron micrographs of sections of tadpole oocyte show the potential for exchange between the nucleus and the cytoplasm at the nuclear envelope. Thin filaments that appear to traverse nu...

Transmission electron micrograph of surface of nuclear envelope of guinea pig spermatocyte prepared by the Freeze-fracture technique shows the unusual clustering of nuclear pores in these cells. From...

A freeze-fractured view of the nuclear envelope. The fracture in the middle of the figure exposes the cytosolic facing membrane. This can be distinguished by a fractured cytoplasmic organelle at the t...

DIV10 torsinA-KO neuron - Placeholder

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (red), a major component of the nuclear lamina. Also shown is the distributi...

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a truncation in the gene for lamin A (red, left image), a major component of the nuclear lamina. The distributio...

Transmission electron micrograph showing the extensive accumulation of darkly stained heterochromatin at the nuclear periphery typical of many differentiated cells. Heterochromatin is excluded from re...

High resolution image of the macronucleus of Coleps hirtus. Heterochromatin and nucleoli are seen as smaller and larger stained bodies, respectively, in the macronucleus. Many nuclear pores exist in t...

Z-series image of mouse ES cells carrying a beta-globin BAC transgene array (clone 8d) and transduced with a lentivirus containing an EGFP-lacI expression cassette. EGFP-LacI binding (green) to the 25...

At DIV10 (Day In Vitro 10), torsinA-knockout (KO) neurons exhibit significant abnormalities in nuclear pore complex (NPC) distribution and nuclear envelope (NE) integrity. As lifelong interphase cells...