Shown are fibroblasts from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (red), a major component of the nuclear lamina. The morphology of the envelop...

DIV10 WT neuron

DIV10 torsinA-KO neuron

DIV10 torsinA-KO neuron

DIV10 WT neuron

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (left image, red), a major component of the nuclear lamina. Also shown is th...

Transmission electron micrograph of a thin section of the nucleus of a HeLa cell expressing a mutant of the nuclear porin ALADIN. The nuclear envelope ultrastructure is not affected by the mutation. ...

DIV10 torsinA-KO neuron - Placeholder

Nuclear envelope and spindle dynamics when the nucleus moves into the neck of kar9delta mutant cells arrested in S phase. Movie plays at 100x real time and is movie S6 in Proc Natl Acad Sci. 2009. 10...

Nuclear envelope and spindle dynamics when the nucleus moves into the neck of kar9delta Nip100deltaCAP-Gly double mutant cells arrested in S phase. In these cells, the spindle failed to enter the bud ...