Starved Dictyostelium cells lacking cGMP-binding protein C (gbpC-; no guanylyl cyclase activity) and in medium supplemented with 60 µM LY294002 (a PI3K inhibitor) and 1µM cAMP migrate toward the ano...

To determine the extent to which extracellular matrix proteins colocalize with the microtubule-anchoring factor LL5s (LL5α), MCF-10A epithelial cells were immunostained with antibodies to the secrete...

Three dimensional data set acquired using a fast z-scan along the apical-to-basilar axis of a polarized epithelial cell in vitro to capture GFP-EB1 comets assosiated with the plus-end of actively poly...

Colorized scanning electron micrograph of a lung cancer cell grown in culture.

Human primary keratinocyte spreading on an asymmetric "arc"-shaped collagen I micropattern. The cells are stained for the focal adhesion protein vinculin (green, Alexa488), F-Actin (red, TRITC phallo...

This total internal reflection (TIRF) image of both the Dronpa-alphaa ctinin and the unconverted tdEos-vinculin channels corresponds to the same image field as the diffraction limited DIC image CIL 38...

This photoactivation localization microscopy (PALM) image of tdEos-vinculin (red) and Dronpa-paxillin (green) illustrates that vinculin and paxillin are segregated into interlocking microdomains withi...

Topographical regulation of keratinocyte migration. 2D, 3D, and 1D fibrillar migration of human epidermal keratinocytes. 2D matrices were constructed by uniform coating with extracellular matrix (ECM)...

Off-axis patterns perturb uniaxial migration, while 1D lines promote conversion to fibrillar migration. Effects of encountering a perpendicular fibrillar pattern during fibrillar migration (top) and c...

This photoactivation localization microscopy (PALM) image of tdEos-paxillin (green) and PsCFP20-zyxin (red) demonstrates that these two focal adhesion proteins are have very little over-lap when visua...