Human colon carcinoma HCT 116 cells were transfected with a GFP-LC3-encoding plasmid, cultured in complete medium for 24 h and treated with vehicle as a control for resveratrol or spermidine treatment...

Saccharomyces cerevisiae (WT BY4741-MATa his3Δ1 leu2Δ0 met15Δ0 ura3Δ0), transformed with EGFP-Atg8p, undergoing chronological aging on small synthetic 2% glucose media (SMD) with supplementation o...

Saccharomyces cerevisiae (WT BY4741-MATa his3Δ1 leu2Δ0 met15Δ0 ura3Δ0) undergoing chronological aging on small synthetic 2% glucose media (SMD) without spermidine supplementation. Image represents...

Human colon carcinoma HCT 116 cells were transfected with a GFP-LC3-encoding plasmid, cultured in complete medium for 24 h and enucleated to obtain cytoplasts. The cytoplasts were treated with vehicle...

Image indicative of 24 h autophagic activity of human colon carcinoma HCT 116 cell co-transfected with a RFP-LC3-encoding plasmid and a SIRT1 fused to GFP plasmid. Confocal fluorescent images were cap...

Human colon carcinoma HCT 116 cells were transfected with a GFP-LC3-encoding plasmid, cultured in complete medium for 24 h and treated with vehicle for 4 h as a control for EX527 and resveratrol or sp...

Human colon carcinoma HCT 116 cells were transfected with a GFP-LC3-encoding plasmid, cultured in complete medium for 24 h and treated with 100µM Spermidine for 4 h. For fluorescence microscopy deter...

Human colon carcinoma HCT 116 cells were transfected with a GFP-LC3-encoding plasmid, cultured in complete medium for 24 h and treated with 100 µM Spermidine in the presence of SIRT1 inhibitor EX527 ...

Transgenic C57BL/6 mice expressing GFP-LC3 fusion protein, uninjected as control for injection with Resveratrol and/or spermidine. To avoid postmortem autophagy induction, dead mice were immediately p...

A high resolution micrograph. Most wild type Tetrahymena have a macronucleus and a micronucleus. The micronucleus, seen here, is essentially nonfunctional during interphase. Its function is to replica...